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Initial Assessment Your physician will likely perform a focused abdominal exam, check vital signs for dehydration (orthostatic blood pressure, heart rate), and order basic labs: a complete metabolic panel (CMP) to assess electrolytes and kidney function, a complete blood count (CBC) to check for anemia or infection markers, and a C-reactive protein (CRP) level to screen for systemic inflammation [18]
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For cell treatment by APAP precursors, HepaRG cells and primary human hepatocytes were first incubated with 50 µg/ml of APAP or APAP-cys in the maintenance medium described above, during 0.5 h, 2 h, 6 h, 24 h, or 48 h, to optimize the incubation time required to detect APAP metabolites