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F2-isoprostanes are associated with an increased perception of pain and are elevated in acutely hyperglycemic diabetics

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It was first isolated in 1977 by Swiss researchers Schoenenberger and Monnier, who identified it in the cerebral venous blood of rabbits that had been induced into an electrically-stimulated sleep-like state — the peptide was named for the specific delta-wave EEG pattern researchers observed accompanying its presence