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This process regulates cellular physiological functions and modulates various injury and disease-related pathological processes ( 2 O 2 ) and metal ions ( 2+ -MPP complexes induce the Fenton reaction with endogenous H 2 O 2 , generating highly reactive •OH radicals that form oxidative stress, which can react with DNA and lipids, causing DNA damage and lipid peroxidation, harming cells and DNA ( 2 O 2 primarily stems from its conversion into hydroxyl radicals (•OH) through ionizing radiation (as shown in reaction a), interaction with copper via Fenton chemistry (as shown in reaction b), or interaction with superoxide anion radicals via the Haber-Weiss reaction (as shown in reaction c)
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