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These are Tremors at rest of hands, legs, and/or jaw Slowness of speed of movements (bradykinesia) Stiffness of limbs (rigidity) Changes in posture, walking or balance difficulties Reduced facial expression (hypomimia) Difficulty in writing Change in voice quality or slurred speech (hypophonia, dysarthria) Difficulty in swallowing food (Dysphagia) ➤ Non-Motor Symptoms of PD: They can occur earlier in the disease before motor symptoms emerge and may be present throughout the course of disease

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Data extraction and synthesis were performed thematically to construct the mechanistic framework and therapeutic overview presented in this review