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Jamun and its active phytochemicals myricetin, quercetin, and cyanidin increase reactive oxygen species formation and DNA damage as well as inhibit the transactivation of inducible nitric oxide synthase (iNOS), nuclear factor kappa B (NFκB), cyclooxygenase (COX) 1 and 2, Bcl2, and tumor necrosis factor (TNFα), leading to cytochrome c release from mitochondria and the activation of caspases and Bcl2-associated X (Bax), which subsequently triggers apoptosis to exert cytotoxic effects on neoplastic cells
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