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IGFBP-rP1 and IGFBP-rP2 have been reported to increase during senescence of the prostate epithelium and in response to growth inhibitors (TGF-β1 and atRA) suggesting they are likely to negatively regulate growth, however the role of IGFBP-rP3 as a growth stimulator and/or protooncogene has been reported after preferential expression in cancerous cells [26]