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That means you cannot legitimately place “10.8% for cagrilintide” next to “24.2% for retatrutide” and declare a winner, because those numbers come from different trials, different populations, different durations (26 vs 48 weeks), different doses, and — critically — a monotherapy figure for one versus a monotherapy figure for the other, while cagrilintide’s strongest data are actually as a combination
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This temporal threshold distinguishes acute from chronic pathology suitable for regenerative approaches, ensuring that less invasive options including physical therapy, NSAIDs, and activity modification have been exhausted before advancing to biologic interventions [60,67]
