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Thus, the pathophysiological consequences of cellular oxidative stress associated with a number of diseases (e.g., Alzheimer’s disease, atherosclerosis) and tissue injuries (e.g., stroke, spinal cord injury) appear to be mediated by endogenous soft electrophiles such as acrolein, 4-hydroxy-2-nonenal (HNE) and 4-oxo-2-nonenal (ONE) that are generated during membrane lipid peroxidation [16], [21], [25], [70], [79]

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Study of ataluren (PTC124 ® ) in cystic fibrosis [online], (2014)

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