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For this reason, any substantial calorie reduction should be guided by a clinician who can determine whether the plan is appropriate and monitor for adverse effects

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Interestingly, there is a remarkable absence of cAMP-responsive elements (CRE) and Ca 2+ responsive elements (CaRE) in the promoter region of POMC despite the demonstrated importance of cAMP and Ca 2+ in the intracellular signaling of corticotrophs and melanotrophs