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The findings for REST further illustrate that the ZF degron that governs binding to CRBN–MGD complexes is more complex than a single ZF and that additional ZF interactions facilitate degradation

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METHODS: Animals were randomly allocated to sequentially receive atropine (0.12 mg/kg by rapid injection), pralidoxime (25 mg/kg by injection during 2 minutes), and hydroxocobalamin (75 mg/kg during 10 minutes) by the intravenous or intraosseous route, or atropine and pralidoxime by the intramuscular route