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BPC-157 and Nicotine Interaction Profile: What the Evidence Says At a glance Drug studied / BPC-157 pentadecapeptide (Arg-Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) Nicotine interaction class / Pharmacodynamic (vascular, dopaminergic, GABAergic overlap) Human RCT data on this combo / None published as of July 2025 Key animal finding / BPC-157 attenuated nicotine-induced aortic and gastric lesions in rat models Alcohol interaction risk / Low-to-moderate