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Both I3AA and I3PA are aryl hydrocarbon receptor (AHR) agonists 59 , which could activate AHR transcriptional activity and modulate inflammation in the gut 60,61,62,63 and brain 64,65

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None of these peptides are currently approved by major regulatory agencies, and while some are used off-label in sports medicine, peptides like TB-500 and GHK-Cu are monitored substances under WADA regulations, raising concerns about doping violations in athletic contexts