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This cardioprotective effect was achieved by inhibiting the expression of the CAMK2D gene (which encodes the structure of the protein CaMKIIδ, whose reduced activity protects the heart from ischemic damage) and inducing gene expression for the CaMKIIN2 protein, which inhibits CaMKIIδ [61]

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Though diabetes authorities recommend annual B12 screening for people who have diabetes and use metformin, many clinics fail to test B12 levels every year, according to an article published in Clinical Diabetes