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MT-II stimulates melanogenesis via MC1R on melanocytes → darker pigmentation following short subcutaneous dosing.¹ In the CNS, MT-II can trigger erections without sexual stimulation, pointing to central melanocortin circuitry (hypothalamic and spinal sites).² Discovery & Research Milestones Discovery & Research Milestones Originated at the University of Arizona in the 1980s, where researchers were exploring sunless tanning agents.¹ Built as a short, stable analog of α-MSH, improving its half-life and activity compared to the natural hormone.² Early studies tested Melanotan-2 in skin pigmentation disorders and sexual dysfunction, but it never achieved regulatory approval