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85 In fact, although a study of Marin-Valencia et al has shown that tumors, derived from transplantation of glioblastoma cells, used glucose to sustain anabolic processes accumulating glutamine, 86 several works have demonstrated the efficacy of glutaminase inhibitors as BPTES (bis-2-(5-phenylacetamido-1,2,4-diathiazol-2-yl) ethyl sulfide) and CB-839 both in vitro and in vivo